Campylobacter Pylori (C. pylori) that had recently been reported have become an interesting objects in the discussion of the etiology of gastritis and peptic ulcer.
The role of the C. pylori was evaluated in groups of adults with pathologic mucosa and with normal mucosa, who visited to Hanyang University Hospital in Seoul, Korea.
By means of culture or Warthin-Starry silver stain, C. pylori was detected in biop-sy materials of 53 (68.8%) out of 77 patients and 1 (7.7%) out of 13 concurrent control subjects (p<0.05). According to the histopathologic gradings, the following numbers were to be positive: active chronic gastritis 41 (75.9%); chronic gastritis 7 (13.0%);; chronic ulcer 5 (9.3%); and histologically normal findings 1 (1.9%). A serological screen-ing that used for a dot immunoassay resulted in the following reports: positive Ig G immunoblot were found in 51(94.4-117o) of the patients with C; pylori and in 11(20.4%) of the patients -without C pylori (p<0.01), and positive Ig A immunoblot were found in 11 (20.4%) of the patients with C. pylori and in zero (0.0%) of the patients without C. pylori (p<0.05). A serologic test used for a Western blot immunoassay resulted in seven strong protein bands (108 KD, 98 KD, 78 KD, 72 KD, 68 KD, and 62 KD).
These findings strongly implicate CC pylori as one of the cause of active chronic gastritis and chronic ulcer. And this study supports the concept that C. pylori may be an important cause of gastritis or peptic ulcer in Korean adults.
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